Attention to 2 factors affecting success in IVF

Higher doses of medication are used to stimulate the ovaries in smoking women and the pregnancy success is lower, Assoc. Dr. Nadiye Köroğlu said, “The most common and most effective treatment method in the treatment of infertility in the world is in vitro fertilization. It is simply a procedure that involves the fertilization of the egg obtained from a woman in vitro fertilization outside the female body in the laboratory and then giving the woman back into the uterus after 3-5 days of follow-up. He said, “In vitro fertilization method can be applied to those who have ovulation problem, both tubes are surgically removed or if there is obstruction in the tubes, if the woman is over 40 years old, if the male has no or few sperm, those with unexplained infertility, those with endometrioma and cancer patients.”


Pointing out that the IVF procedure is applied in 6 steps, Assoc. Dr. Köroğlu said, “First, the ovaries are stimulated with drugs. In vitro fertilization is started on the second or third day of the mother’s menstrual cycle after ultrasound and, if necessary, hormonal values ​​are checked. Since the purpose of IVF treatment is to ensure the development of a large number of eggs, hormone drugs are given to stimulate the ovaries. Although it varies between 8 and 14 days, it takes 10-11 days on average. During these periods, you need to come to the hospital 2-3 times for ultrasound control and hormone tests. The number of developing follicles (sacs that are thought to contain egg cells) is a factor that directly affects the chance of pregnancy. The initial dose of hormone injections is determined according to the age, weight, serum AMH level of the woman and, if any, the treatment response in previous trials. When the follicles reach 18-20 mm, a cracking injection is made for the eggs to mature. “


Assoc. Dr. Köroğlu said, “After 34 to 36 hours of making this maturing needle, the eggs are collected by a thin needle by ultrasonography performed vaginally. Since anesthesia will be given during this procedure, no pain or discomfort is felt. It is a short process of about 10-15 minutes. A mild pain may be felt on the day of the procedure. Then, the fluid inside the follicles is examined by the embryologists and the quality and maturity of the oocytes are determined. A good quality sperm selected by embryologists is placed in mature eggs under a microscope. After fertilization, embryos are followed in special devices that imitate the uterine environment in the best way. Then, it is followed in the laboratory environment for 3-5 days ”.


Stating that the embryo formed in the fourth step was placed in the womb of the expectant mother, Assoc. Dr. Köroğlu continued as follows: “The highest quality embryo is selected according to the developmental stage among the formed embryos. Although it is done between the 2nd and 5th days with the transfer process, the embryo transfer is made on the 5th day at most. The most important criterion when determining the number of embryos to be transferred. woman’s age and previous tubes are baby trial. according to the regulations in Turkey in the first two test-tube baby in women under the age of 35 1 embryos, maximum two embryos can be transferred in the next trial. in women over 35 years of age, regardless of previous IVF attempt more than 2 embryos Embryo transfer is the most important step in IVF treatment.Embryo transfer is done under ultrasound control when the woman is very congested with urine. With the help of a catheter, the embryos are left in a suitable area without touching the uterine wall. After this procedure, the patient’s resting increases the pregnancy rate. unity with absence After being followed up in the clinic for a short time, he is sent home. After the transfer, if there are good quality embryos, they can be frozen and stored in the center if the couples wish. “


Assoc. Dr. Köroğlu said, “After the transfer process, progesterone hormone is given to support the adherence of the embryo to the uterus. Progesterone hormone can be administered orally, as an injection or vaginally. Medication support is continued until the pregnancy test day. During this period, there may be pain in the groin, discharge in the form of spotting and tenderness in the breasts. Finally, a pregnancy test is done 12 days after the transfer, ”he said.


Assoc. Dr. Drawing attention to the two main factors affecting the success of IVF treatment, Köroğlu ended his words as follows: “The age of the expectant mother and smoking affect the success of the treatment. The most important factor affecting the success of IVF treatment is the age of the expectant mother. The younger the expectant mother is, the higher the chance of pregnancy in IVF. While the live birth rate for a woman under the age of 35 is between 40 and 50 percent, this rate is around 4 percent for a woman over 42 years old. As the age of the expectant mother increases, both the number and quality of eggs decrease, which is the most important factor affecting the success of IVF. Smoking couples is also one of the factors affecting the success of IVF. In smoking women, higher doses of medication are used to stimulate the ovaries, pregnancy success is lower and more IVF attempts are required compared to non-smokers. “

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