What is the HIPEC method? How is hot chemotherapy applied? What are the treatment methods that prevent cancer spread?


04 April 2021 Sunday – 17:00 | Last Updated: 04 04 2021 – 17:00

Providing information about the HIPEC method, which is used in intra-abdominal cancer spread and described as the application of warm chemotherapy in the abdomen, Health Sciences University Koşuyolu High Specialization Training and Research Hospital Gastroenterology Specialist Assoc. Dr. Selçuk Gülmez said, “In the HIPEC method, which is applied in intra-abdominal cancer spread, higher doses of chemotherapy can be given than intravenous application. This can make it more effective locally.”

Health Sciences University Koşuyolu High Specialization Training and Research Hospital Gastroenterology Specialist Assoc. Dr. Selçuk Gülmez stated that in the HIPEC method, which is applied in intra-abdominal cancer spreads and described as the application of warm chemotherapy in the abdomen, higher doses of chemotherapy can be given compared to intravenous application, “This can make it more effective locally.” said.

Assoc. Dr. In his statement, Gülmez gave information about the HIPEC method, which is described as the application of warm chemotherapy in the abdomen.

Expressing that HIPEC can be applied at higher doses in the abdomen compared to intravenous administration of chemotherapy drugs, Gülmez said that the hot chemotherapy process is applied at 41-43 degrees Celsius, while this temperature does not harm the patient, it does not harm the tumor cells and allows chemotherapy to penetrate more into the tumor tissue. He said it resulted in increased drug efficacy.

Explaining that this method has less systemic side effects compared to intravenous administration, Gülmez said:

“In addition, since the blood flow of the peritoneum is towards the liver, the destructive effect of chemotherapy on possible liver micrometastasis (spread) can be considered as another positive feature.

Likewise, it is also necessary to mention the tumor cell-destroying effect in these areas, as some drugs are additionally transported to the systemic circulation via lymphatics. In the case of malignant tumors of the gelatinous appendix (pseudomyxoma peritonei) and abdominal lining (mesothelioma), stomach, colon and ovarian (ovarian) cancers, this treatment can be applied at the time of initial diagnosis or after several courses of intravenous chemotherapy. The main requirement is that patients must be fit. In other words, it is important that the person is doing his own business without help. Although there is a limit of 70 for age, it is based on fitness. This treatment can be repeated when there is a recurrence in the abdomen in a person who has undergone hot chemotherapy. Prophylactic, in other words, hot chemotherapy for prevention is also applied to patients who have not spread into the abdomen but have protruded from the organ from which the tumor tissue originates. “

“IT IS POSSIBLE TO ACHIEVE SATISFACTORY RESULTS WITH SUITABLE PATIENT SELECTION”

Assoc. Dr. Selçuk Gülmez stated that the surgery can be a heavy process and can take an average of 8-10 hours, but sometimes even longer, continued as follows:

“Sometimes it may be inevitable to remove multiple organs during surgery. The aim is that there should be a maximum of 2.5 millimeters of metastatic tissue remaining in the abdomen after surgery. At the end of the operation, patients are taken into intensive care for at least one day. Patients may need a recovery period of approximately two weeks. Meanwhile, it is possible to reach the final pathology results. After the result is shared with the surgical team, several sessions of chemotherapy treatment by the oncology are inevitable. As a result, it is possible to achieve satisfactory results with the appropriate patient selection.


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