Many people initially kept a distance from the BioNTech vaccine, claiming that the mRNA technology used in the BioNTech vaccine is new, and it is not yet known what problems a vaccine developed in such a short time will cause in the long run. Prof. Dr. Osman Müftüoğlu shared what should be known about mRNA vaccines in his article today.
Many people initially kept a distance from the BioNTech vaccine, claiming that the mRNA technology used in the BioNTech vaccine is new, and it is not yet known what problems a vaccine developed in such a short time will cause in the long term. They were not considered unfair either. Let me admit, I had the same “distant stance” when I was watching the first studies on BioNTech in September 2020. Initially, Health Minister Dr. I guess that Fahrettin Koca had the same opinion, more precisely, he made a statement in this direction. But let’s admit that the information coming from the field and the scientific studies published later made us all comfortable.
The mRNA technology used in the production of the BioNTech vaccine is actually not as new as it seems. Although BioNTech is the first mRNA vaccine to be approved, scientists – especially those doing research in the field of oncology / cancer – have already been working extensively on mRNA vaccines for years. What was achieved with the discovery of BioNTech consists of using the logic of “developing immunity with mRNA” in “developing a vaccine against the new coronavirus”. But the trick is here, in this detail, to think what not everyone thinks and to bring it to life, isn’t it?
The “synthetic messenger RNA (mRNA)” developed by BioNTech is like a “smart missile” that carries the genetic instructions that enable the spiny protrusions (Spike protein) on the surface of the new coronavirus, which is the cause of COVID-19 disease, to be produced by the cells in our body. A greasy nanoparticle sheath was used to allow synthetic mRNA to easily enter our cells after inoculation and prevent degradation, which is an excellent technique.
Immediately after the BIONTECH vaccine is injected into the upper arm muscle, it is immediately taken by our “special cells / macrophages” near the injection site. mRNA sends these cells / macrophages to “Produce Spike / Spike (S) protein!” giving his order. This “new and foreign” protein produced in macrophages comes to the surface of macrophages and stimulates our immune system, which protects us from infections. As a result, it causes a strong “immune response”. While our B lymphocytes produce a lot of “antibodies” on the one hand, on the other hand, our T lymphocytes record that information in their memory and activate the “cellular immunity”.
As for the “artificial / synthetic mRNA” that enters our body during vaccination and activates immune responses that will protect us … Don’t worry. He cannot do us any harm. It is broken down and destroyed by enzymes in our body within 2-3 days at the latest.
Initial “clinical trials” and later “mass vaccination applications” showed that the efficacy achieved after the first dose of BioNTech vaccine was much higher than expected. Moreover, this vaccine was able to provide some protection in most people just two weeks after the first dose. Naturally, the strong efficacy achieved after the first dose brought up the idea of ”being content with 1 dose” instead of applying “a 2-dose schedule” and thus “delivering the vaccine to 2 times more people”. Although, after the first dose of BioNTech, a “level of immunity to work” is usually obtained, let’s know that the second dose must be administered to reach the “95 percent efficiency” point in the vaccine. Existing data also support this information. Administering the second dose makes the achieved immunity stronger, longer lasting and durable. As a result, one should never give up 2 doses.
When infectious diseases and public health experts saw that the BioNTech vaccine “reduced the likelihood of COVID-19 by about 95 percent compared to placebo vaccines”, naturally, they were extremely hopeful. Because the evidence at hand was very strong. Because BioNTech was able to prevent not only any disease related to SARS-COV-2, but also, much more importantly, “SEVERE COVID-19”. In short, preventing a severe and severe or even fatal disease state could turn COVID-19 from a global threat into a more reasonable nuisance such as “flu or cold”. I also have this opinion. If we can continue the vaccination at the speed and intensity specified by our Minister of Health, we can easily say “Wait for us in autumn”.
A subject that is frequently brought to the agenda is the issue of “the frequency and severity of allergic reactions that can be seen in BioNtech vaccine”. Let us be clear and unambiguous that allergic reactions in this vaccine are less common than those mentioned. Current figures suggest that ‘anaphylaxis’, which is considered the most severe of allergic reactions, can occur in about 2 to 5 people per million vaccinated. Although these numbers seem higher than other vaccines, they are much lower than the threat of “penicillin anaphylaxis”, which is estimated to be “1 in 10,000”, for example. Of course, let’s be cautious, but let’s not overdo the allergy issue.
It is true that all Covid-19 vaccines are developed and implemented much faster, even at an extraordinary rate, than vaccines developed at all times. The first studies on BioNTech started 1 year ago, in the last summer. The application was quickly started about 6 months ago. Let’s know that, in principle, the main problems in vaccination processes occur within the first days and weeks after the application. Long-term side effects that may occur with vaccines are generally very rare, and are considered to be negligible considering the benefits.
If we want to prevent the epidemic as soon as possible, if we want to put a cross on the pandemic and return to our old, pleasant, happy, peaceful days and do not want to sing the song “lost years” over and over again, we have only one option: TO BE INSURED! In a large observational study in Israel, those who were vaccinated had a 90 percent reduction in the risk of asymptomatic COVID-19 compared to those who were not vaccinated. We also know clearly and clearly that the “viral load” carried by people who are infected after vaccination is much less than those who are infected while not vaccinated. This information also means that vaccinated people are less likely to transmit the disease due to low viral load. But let’s also know that none of the available vaccines “never 100 percent guarantee that we will catch the virus and / or pass it on to others”. For this reason, we can summarize our strategy as vaccinating as many people as possible, paying attention to protection and protection until the vaccination is completed and the whistle of the pandemic is over, “to wear our masks in public places, to protect our social distances of 2 meters and to stay away from crowded indoor environments”. we need to persistently continue.
If you have any of the following conditions, please inform your doctor and / or vaccination center before being vaccinated: – If you are an allergic person – You have had an allergic reaction after any vaccination in the past – If you are receiving any anti-allergic treatment – If you have a blood clotting problem – If you are taking any anticoagulant medication – If you are pregnant, especially in the first 3 months.